Cardiac, CT, CT-Quantitative, Comparative studies, Ischaemia / Infarction
G. Pontone1, D. Andreini1, A. L. Bartorelli1, M. Guglielmo1, S. Mushtaq1, C. Segurini1, A. Baggiano1, E. Conte1, V. Beltrama1, A. D. Annoni2, A. Formenti1, M. Petullà1, A. I. Guaricci3; 1Milan/IT, 2Milano /IT, 3Foggia/IT
Coronary artery disease (CAD) is a major cause of mortality and morbidity (1) and the identification of CAD patients at high risk of adverse events is crucial.
Several non-invasive stress tests (NIST) are commonly used as gatekeepers to invasive coronary angiography (ICA).
the diagnostic yield of the invasive procedure is still low (2,
Coronary computed tomography angiography (cCTA) has been recently introduced as an alternative imaging modality to rule out CAD (4,
5) with low radiation exposure (6) and the potential for improving prognostic assessment (7-9).
the limited positive predictive value of cCTA,
particularly in the presence of calcified coronary lesions (10,
11) is frequently responsible for overestimation of CAD (12) .
In this regard,
new cCTA techniques such as fractional flow reserve CT derived (FFRCT) (13-15) and stress computed tomography perfusion (stress-CTP) (16,
the aim of this study is to compare the feasibility and diagnostic accuracy of FFRCT versus stress-CTP for the detection of functionally significant CAD,
using invasive FFR as the reference standard.