Purpose
Non-fracture osteopenia reflects the decline in bone mineral density without clinical manifestations characteristic of osteoporosis and of greatest interest for timely early prevention of osteoporosis and its complications.
The relationship processes and ectopic bone formation of arterial calcification is shown in the results of many studies.In calcified plaques was detected ectopic bone,
and in the walls of arteries and marked cells like osteoblasts andosteoklasts[1].
Numerous cellular and molecular components such as collagen type I,
osteonectin,
osteopontin,
osteoprogerin,
oxidized lipids,
regulate processes such as bone and...
Methods and Materials
We studied 186 male (60 ± 6,7 years) with multifocal atherosclerosis.
All the patients underwent the measurement of BMD with X-ray absorptiometry.
Moreover,
calcium scores (CS) of coronary and brachiocephalic arteries were obtained using Agatston method bymultislice CT (Siemens Somatom Sensation 64).
Evaluation of bone mineral density were performed on Norland XR 46 (Norland,
USA) according to the standard program,
which included the X-ray absorptiometry of the proximal femur in the frontal projection.
The degree of reduction in bone mineral density was evaluated by T-score...
Results
Among the patients had a high prevalence of osteopenia syndrome (87.1%).
According to X-ray absorptiometry T-score values of lumbar vertebrae -1.07 [-1.54; -0.40],
T-score of the proximal femur -2.01 [-2.71; -1.49].
We also found a large amount of calcification of the coronary arteries according MSCT: calcium score (CS) 471.8 [118.2; 916,8].
Severe calcification of the coronary arteries is predominant in the examined group of patients (fig.1).
Calcification of the carotid arteries in patients of the study group was less pronounced: CS 113.9 [44.5; 300.8],
but...
Conclusion
The study results suggest that indicators of calcification of the carotid and coronary arteries resulting from a routin examination by MSCT of patients with multifocal atherosclerosis have a high predictive capacity for assessing the probability of the presence of osteopenic syndrom in this category of patients.
References
1.
Tintut Y,
Parhami F,
Tsingotjidou A et al.
8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway.J Biol Chem.
2002;277:14221-14226.
2.Doherty TM,
Fitzpatrick LA,
Inoue D et al.
Molecular,
Endocrine,
and Genetic Mechanisms of Arterial Calcification.Endocr Rev.
2004;5: 629-672.
3.Broussard D.L.,
Magnus J.H.
Coronary heart disease risk and bone mineral density among U.S.
women and men.J Women’s Health.
2008;17:479-90.
4.Schulz E,
Arfai K,
Liu X et al.
Aortic calcification and the risk of osteoporosis and...