Arteriosclerosis, Diagnostic procedure, CT, Cardiovascular system, Cardiac
D. K. Galaska, R. Galaska, J. Fijalkowska, M. Fijalkowski, A. Wegrzyn, E. Szurowska, M. Gruchala; Gdansk/PL
FH patients with LDLR mutation have an increased AVCS as assessed by computed tomography calcium scores in comparison to patients with not genetically confirmed severe hypercholesterolemia.
LDLR mutation is an independent risk factor of having high AVSC,
even after adjustment for risk factors including cholesterol levels.
These findings confirm that the evolution of aortic valve calcifications in patients with familial hypercholesterolemia appears to be,
at least in part,
independent of cholesterol levels and may result from associated processes connected with the regulatory role of LDLR in osteogenic signaling pathway.