Keywords:
Lung, Respiratory system, Thorax
Authors:
A. Mahajan1, S. Sripathi2, V. R. K. Rao2, M. Thakur1; 1Mumbai/IN, 2Manipal/IN
DOI:
10.1594/ecr2010/B-276
Purpose
INTRODUCTION:
An increasing number of vascular-modulating drugs are used in the treatment of cancers, which in turn increase demand for noninvasive methods of assessing tumor vascularity in vivo.
Perfusion CT is a new technology that allows measurement of tumor vascular physiology .
Apart from being noninvasive and fast, it can be repeated at regular intervals to assess tumor response to antiangiogenic therapy.
AIMS AND OBJECTIVES
To prospectively investigate the feasibility and value of 64-slice MDCT in first-pass perfusion imaging of lung tumor perfusion.
Differentiate CT perfusion (CTP) parameters in malignant tumors from benign lesions.
To analyse the variation of CTP parameters in different histological types, sizes and presence of tumor necrosis in patients with lung carcinoma.
To correlate changes in CT Perfusion (CTp) parameters following neo-adjuvant chemotherapy (antiangiogenic therapy)with changes of tumor perfusion.
To evaluate whether baseline CTp may predict tumor volume changes following therapy.