To present several examples of perfusion CT studies performed on different parts of the body.To describe specific perfusion CT findings of many benign and tumoral pathologies.To understand the role of perfusion CT in evaluation of many diseases.
An increasing number of vascular-modulating drugs are used in the treatment of cancers, which in turn increase demand for noninvasive methods of assessing tumor vascularity in vivo.Perfusion CT is a new technology that allows measurement of tumor vascular physiology .Apart from being noninvasive and fast, it can be repeated at regular intervals to assess tumor response to antiangiogenic therapy.Here many clinical applications of perfusion CT using 64 slice MDCT scanner are presented.
Imaging findings OR Procedure details
467 lesions prospectively studied from January to Dec 2008.36 brain lesions98 head and neck pathologies11 spinal pathologies11 breast malignancies26 esophageal pathologies142 lung pathologies101 abdominal pathologies42 pelvic pathologiesCT perfusion was performed with a 64 –slice MDCT.Tumor was localized and a 4-cm lesions region was selected independently for the dynamic study .Contrast bolus infusion at a rate of 50 mL at 5 mL/sec for 10 seconds, followed by a saline flush at 40 mL at 5mL/sec for 8 seconds.Total 30 dynamic acquisitions with inter - cycle interval...
Finally we conclude that perfusion CT is useful for quantitative analysis of perfusion changes in many ischemic and tumoral pathologies.Therefore perfusion CT tool may be helpful in oncology, providing a higher degree of diagnosis security, differentiation in malignancy and for the therapeutical follow-upOne of the important applications of this technique is the indication of a highly perfused area, which could be used to guide biopsy to the site of the most active tumour, reducing the chance of sampling error.In future, pre and post treatment tumor...
Author details:Dr. Abhishek Mahajan, MBBS,MDFellow in Cancer ImagingDept of Radiodiagnosis & ImagingTata Memorial HospitalDr E Borges RoadParelMumbaiMaharashtra400 012India(+919920354764)firstname.lastname@example.org
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