Keywords:
MR, Computer Applications-Detection, diagnosis, Metabolic disorders, Liver
Authors:
I. Sansoni, C. L. Piccolo, F. Pitocco, R. Del Vescovo, R. Setola, B. Beomonte Zobel; Rome/IT
DOI:
10.1594/ecr2012/C-1433
Methods and Materials
20 patients (13 male and 7 female; age: 32-70 years) with a diagnosis of non-alcoholic liver steatosis (NAFLD) based on clinical lab tests and liver US evaluation were enrolled.
They underwent MR examination (1.5 T Superconducting magnet: Magnetom Symphony,
Siemens; high performing gradients - 30 mT / m),
bioumoral tests and anthropometric evaluation at basal time.
Then they started a standardized diet; after three months of dietetic therapy they underwent new clinical evaluation, lab tests and MR examination.
Using GRE MR T1-weighted and TSE T2-weighted sequences with and without fat saturation (6 breath-hold axial sequences: 4 GRE T1-w sequences with IN/OUT phase TE,
2 TSE T2-w sequences with/without fat saturation),
HFF (hepatic fat fraction) was measured and its percentage of variation was quantized.
We compared the variation of average HFF with variation of BMI and FT.
Average HFF variation has been compared with HFF variation in each MR sequence.
All measurements were performed both manually and using Liver Sight ,
presenting them via summary tables and/or via some color maps.
We compared results from manual and FLA evaluation.