Keywords:
Tissue characterisation, Cysts, Blood, Technology assessment, Diagnostic procedure, Computer Applications-Detection, diagnosis, Ultrasound, Experimental, CAD, Oncology, Breast
Authors:
P. Otto1, K. Kist1, C. N. Dornbluth1, B. M. McCorvey1, J. Zalev1, T. G. Miller1, B. A. Clingman1, S. A. Ermilov2, A. Oraevsky2; 1San Antonio, TX/US, 2Houston, TX/US
DOI:
10.1594/ecr2012/C-2403
Results
Experiments in an optically scattering phantom mimicking a blood vessel in the breast demonstrated capability of the opto-acoustic imaging system to detect blood vessels at the depth of at least 6 cm. After the system was calibrated in phantoms,
a feasibility study was performed on female patients with breast masses having BIRADS scores of 4 and 5 and who were scheduled for biopsy.
Initial studies on 32 patients demonstrated that the combined opto-acoustic / ultrasound imaging system can detect areas of high optical absorption in the region of the tumors,
confirmed with ultrasound,
across varying tissue densities.
Opto-acoustic maps,
obtained at two different wavelengths (755 nm from Alexandrite laser and 1064 nm from Nd:YAG laser),
provided information for differentiation of breast carcinomas from benign tumors based upon differences in the optical absorption of hypoxic and normally oxygenated blood in the region of the tumor.
A new method of image processing that enhances [THb] and [SO2] depiction was utilized for images in Fig.4 and Fig.5.
Fig. 4: 4. This panel depicts coregistered ultrasound and opto-acoustic images of a mass, which was graded BIRADS 5 and scheduled for biopsy. Biopsy showed invasive lobular carcinoma, which matches differentiation based on the images: enhanced concentration of hypoxyc blood in the tumor.
Fig. 5: 5. This panel depicts coregistered ultrasound and opto-acoustic images of a mass, which was graded BIRADS 4b and scheduled for biopsy. Biopsy showed fibroadenoma, which matches differentiation based on the images: not enhanced blood concentration in the tumor and normal level of blood oxygen saturation.