Purpose
For the patients with chronic obstructive pulmonary disease (COPD),
pulmonary function tests have been used to assess the global status,
and low attenuation area (LAA) volumetry has been used for pulmonary emphysema evaluation.
Each method has some essential problems which prevent us from assessing COPD correctly.
Pulmonary function tests are not well acceptable for those who have severe lung disease or those who cannot undergo spirometer properly because of their personal problems,
i.e.
age,
general conditions,
etc.
LAA volumetry depends on the threshold of CT...
Methods and Materials
Patients:
Institutional review board approval and written informed consent were obtained.
The study was performed in twenty patients with COPD (mean age: 72 years,
range: 56-87 years)and ten healthy volunteers(mean age: 30 years,
range: 25-38 years).
Patients information are summarized in Table 1.
Xenon-CT Protcol:
35% concentration xenon gas was produced by using a xenon control system (AZ-725 Xetron ; Anzai Medical,
Tokyo,
Japan) .
Xenon ventilation CT data were obtained after single vital-capacity inspiration of 35% xenon gas,
using dual-source and dual-energytechnique after conventional...
Results
For all subjects,
we could successfully undergo xenon ventilation CT and obtained xenon enhanced images calculated with three-material-decomposition method.
No significant complications were noted with 35% xenon gas inhalation in all cases.
In all healthy volunteers,
xenon distribution in the lung fields were homogeneous and showed no distribution defect.
In case of COPD,
total decrease of xenon enhancement values and inhomogeneous distribution of xenon gas in the lung fields were well demonstrated in two and three dimensional images in all twenty cases(Figure1).
Mean xenon enhancement...
Conclusion
Novel technique of single inhalation xenon ventilation CT using dual-energy technique is safe and acceptable examination which has the potential to evaluate both emphysematous and air way type COPD.
It also hasthe potential to predict respiratory function with calcuating mean xenon value of bilateral lung field.
References
・ Chae EJ,
Seo B,
GooHW,
et al.
Xenon Ventilation CT with a Dual- Energy Technique of Dual-Source CT: Initial experience.
Radiology 2008; 248: 615-624.
・ Goo HW,
Yang DH,
Hong SJ,
et al.
Xenon ventilation CT using dual-source and dual-energy tecnnique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results.
Pediatric Radiology 2010; 40:1490-1497.
・ Goo HW,
Chae EJ,
Seo JB,
et al.
Xenon ventilation CT using a dual-source dual-energy technique: dynamic ventilation abnormality in a...
Personal Information
Masahiro Kobayashi,
Department of Radiology,
Toho University Medical Center Omori Hospital,
Tokyo,
Japan;
[email protected]
Nobuyuki Shiraga,Department of Radiology,
Toho University Medical Center Omori Hospital,
Tokyo,
Japan
Yoshiyuki Okada,Department of Radiology,
Toho University Medical Center Omori Hospital,
Tokyo,
Japan
Kenichi Suzuki,Department of Radiology,
Toho University Medical Center Omori Hospital,
Tokyo,
Japan
Keishi Sugino,Department of Respiratory Medicine,
Toho University Medical Center Omori Hospital,
Tokyo,
Japan
Sakae Homma,Department of Respiratory Medicine,
Toho University Medical Center Omori Hospital,
Tokyo,
Japan