Purpose
Leukoaraiosis is characterized by white matter hyperintense lesions (WMHRL) on T2-weighted magnetic resonance imaging (MRI) as the frequent finding of brain aging (1).
WMHRL indicate a strong relationship between age,
arterial hypertension,
diabetes and other vascular risk factors(2.3).
However,
the genetic predisposition is thought to be closely related in terms of leukoaraiosis.
Histological underlying causes are decreased myelin,
axonal loss and astrocytic gliyozis (4.5).
Population-based epidemiological studies,
suggests the link between cognitive performance,
psychomotor deceleration and balance disorder of elderly people who have WMHRL.
Healthy...
Methods and Materials
Leukoaraiosis is characterized by white matter hyperintense lesions (WMHRL) on T2-weighted magnetic resonance imaging (MRI) as the frequent finding of brain aging (1).
WMHRL indicate a strong relationship between age,
arterial hypertension,
diabetes and other vascular risk factors(2.3).
However,
the genetic predisposition is thought to be closely related in terms of leukoaraiosis.
Histological underlying causes are decreased myelin,
axonal loss and astrocytic gliyozis (4.5).
Population-based epidemiological studies,
suggests the link between cognitive performance,
psychomotor deceleration and balance disorder of elderly people who have WMHRL.
Healthy...
Results
A total of 32 Leukoaraiosis patients between the ages of 55-90,
11 males,
21 females,
and in the same age range 36 people who had no leukoaraiosis a total of 15 men and 21 women were examined with color Doppler ultrasound examination for atherosclerotic intima-media thickness,
degree of stenosis and plaque types and statisticaly analyzed using Mann Whitney U test,
Fisher's exact chi-square test,
the data were Pearson's test.
AGE
N
Mean ±std.deviation
Median
Minimum
Maximum
Patients
32
77,69 ± 7,79
81,00
60
88
Control...
Conclusion
Pathophysiological processes in the brain has been the subject of many research.
The aim of our study,
was to assess the contribution of pathological changes in the carotid arteries in advanced age patients with patchy periventricular hyperintensities on MR compatible with leukoaraiosis.
Failure of the vascular system is believed to cause leukoaraiosis in the white matter of the brain (2),
but the pathogenesis is not fully cleared.
Recent studies show that brain vascular structures significant differences between,
leukoaraiosis observed patients and healthy people.
leukoaraiosis patients,...
References
1.
Hachinski VC,
Potter P,
Merskey H.
Leukoaraiosis.
Arch Neurol 1987; 44: 21–23.
2.
Pantoni L,
Garcia JH.
Pathogenesis of leukoaraiosis: a review.
Stroke 1997; 1,44: 652–659.
3.
Murray AD,
Staff RT,
Shenkin SD,
Deary IJ,
Starr JM,
Whalley LJ.
Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people.
Radiology 2005; 1: 251–257.
4.
Janota I,
Mirsen TR,
Hachinski VC,
Lee DH,
Merskey H.
Neuropathologic correlates of leuko-araiosis.
Arch Neurol 1989,1124-1128.
[Published correction appears in Arch Neurol 1990; 46 :...