Keywords:
Neoplasia, Molecular, genomics and proteomics, Cancer, Statistics, Molecular imaging, Biopsy, PET, MR, Mammography, Oncology, Breast
Authors:
F. H. H. Müller1, M. Hentschel2, E. Gilman3, J. Farahati3; 1Ludwigshafen/DE, 2Bern/CH, 3Bottrop/DE
DOI:
10.1594/ecr2013/C-2356
Methods and Materials
PEM was performed (2) on 68 women with suspicious breast lesions 90 min after i.v.
application of 3.5 MBq F-18-FDG per KG body weight.
The technique is shown on Fig.
1.
70 lesions were identified,
because 2 women showed 2 maligne lesions at once as displayed on Fig.
2.
A ROI around the target lesion,
measured the maximum PEM uptake value (PUVmax) and was correlated with a corresponding non-target ROI in the contra lateral healthy breast determining the target / non-target ratio.
Two independent readers analyzed images of all 70 lesions and compared the results to histopathology (11 PEM - Biopsies / 8 Breast - Cancers including 2 double lesions) later as shown on Fig.
3.
The PEM device allowes to do a biopsy easily in one session together with the diagnostic PEM.
No other FDG dose is required.
The biopsy procedure (3) takes 20 - 30 minutes.
The two suspicious double lesions could be biopsied through one biopsy channel one after an other.
The quantitative data for all malignant,
benign,
corresponding non-target lesions and the mean target / non-target ratio were analyzed using a paired Student t-Test.