Keywords:
Diagnostic procedure, MR, Musculoskeletal soft tissue, Musculoskeletal bone, Bones, Inflammation
Authors:
V. A. BRATU, K. Hostettler, A. Fischmann, M. Tamm, U. STUDLER; Basel/CH
DOI:
10.1594/ecr2013/C-2656
Results
WbMRI showed changes in all 24 (100%) patients.
In 8/24 (33%) patients lesions with confidence level 2 and 1 were noted (Fig.
2).
5/24 (21%) patients showed skeletal lesions,
one patient having a disseminated edema-like skeletal manifestation highly probable of sarcoidal origin.
Muscular findings were seen in 3/24 (13%) patients,
one of which had a nodular lesion histologically proven to be a sarcoid nodule.
The cases with MR-findings of confidence 2 and 1 had a higher mean ePOST score (17.3 vs.
10.6,
p<0.02),
confirming a higher extrapulmonary disease activity (Fig.
3).
Patients with elevated creatine kinase levels showed muscular MR-findings more frequently (p<0.02).
There was no significant difference in ACE and sIL2-R levels between patients with and without sarcoidosis lesions of confidence ≥ 1 on wbMRI.
Similarly,
there was no dependency of the MR findings on the rest of laboratory and clinical data.
The prevalence of musculoskeletal findings was significantly higher (p<0.01) in patients with reduced DLCO (Fig.
4). Skeletal findings were significantly more frequent in patients with reduced total lung capacity,
forced vital capacity and DLCO,
respectively (p<0.02) (Fig.
5).
The patients displaying skeletal disease manifestations at wbMRI also had significantly lower lung capacities (p<0.01).