The obtained data of the comparative analysis evidenced a high efficiency of CBCT in diagnostics and dynamic researches of a number of injuries and diseases of upper and lower extremity's distal segments. CBCT showed a high efficiency (Se, Sp, Ac – 100%) at the detection of small areas of pathological remodeling and post-traumatic changes of the bone tissue, which size was less than 1 – 2 mm. Taking into consideration significant advantages of CBCT (high quality of images, low dose, lack of significant artifacts from high density materials and an opportunity to assess a state of dense soft tissue structures and to identify an accumulation of fluid excess in the joints, synovial bursas and tendon sheaths) it is necessary to revise an algorithm of examination of such patients. CBCT can be recommended as a priority method of the first stage for diagnostics and dynamic researches of injuries and diseases for such complex anatomical segments by its compound, as wrist, foot, ankle and hand, where summational effect pronounced mostly on SR.