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Keywords:
Musculoskeletal bone, Bones, Oncology, MR, CT, PET-CT, Biopsy, Diagnostic procedure, Cancer, Metastases, Haematologic diseases
Authors:
B. Lange1, M. L. Nielsen2, J. D. Andersen2, H. J. Lilholt2, M. Vyberg2, L. J. Petersen2; 1Hilleroed/DK, 2Aalborg/DK
DOI:
10.1594/ecr2015/B-0828
Methods and materials
Patients with SNOMED (Systematized Nomenclature of Medicine) codes for skeletal cytology and histology biopsies from Institute of Pathology,
University Hospital of Aalborg,
Denmark,
from January 1,
2011 to July 31 2013,
were identified.
Biopsies with no diagnostic imaging 6 months prior to when the biopsy was taken were excluded together with biopsies unsuitable for diagnosis,
autopsies from fetuses,
material from provoked abortions,
biopsies where there was no diagnostic imaging from the topography from where the biopsy was taken,
and biopsies that had inadequate image description of the exact collection location.
If both a histological and a cytological biopsy were taken from the same patient's same anatomy,
the cytological biopsy was disregarded.
In case more than one relevant biopsy was available within a period of 6 months,
only the first was included.
If more than one biopsy was collected from the same topography within 6 months with both a benign and a malignant diagnosis,
the malignant was accounted for.
If more than one biopsy with identical diagnosis was collected within 6 months from the same topography with the same result,
the first one was accounted for.
In case two or more identical diagnostic imaging procedures were performed within the 6 months period,
we included the most recent.
All pathology diagnoses and imaging descriptions were read by two independent readers.
Necessary approval were acquired.
Diagnostic accuracy was calculated as sensitivity,
specificity and positive and negative predictive values using unpaired t test with 95 % confidence interval for the statistical analysis.