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Keywords:
Neoplasia, Cancer, Staging, Chemotherapy, MR, Oncology, Breast
Authors:
S. Monzawa1, S. Yuen1, N. Yuasa2, H. Kubota1, K. Yamagami1, T. Deai2, H. Matsumoto1, K. Sugimura1; 1Kobe /JP, 2Kobe/JP
DOI:
10.1594/ecr2015/C-0455
Conclusion
Discussion
The definition of complete response has not been established and may vary with institutions.
The residue of intraductal tumors was treated as positive in the present study.
Late phase images were superior to early phase images for the depiction of residual disease.
This may be due to the decrease of blood supply subsequent to degeneration and necrosis of tumor tissues and progression of fibrosis induced by chemotherapy.
Negative predictive value was 0.67 and it was not high enough,
therefore,
dynamic MR imaging may be insufficient for the detection of residual disease.
False negative results were seen in the patients with minute invasive lesions or scattered intraductal tumors.
False positive results might be caused by fibrous scar tissue or fibrocystic disease.
The limitations included small study population,
unfixed chemotherapy protocol,
and retrospective review and analysis by a single observer.
Conclusion
Small residual disease may be difficult to detect and show a false negative finding.
Late phase images are useful for the depiction of residual disease.