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Thorax, Lung, Oncology, CT, Computer Applications-3D, Cancer
R. Peters1, M. Heuvelmans1, S. Brinkhof1, P. M. Van Ooijen1, M. Oudkerk1, P. A. de Jong2, R. Vliegenthart1; 1Groningen/NL, 2Utrecht/NL
3392 participants (84.4% male,
median age 59 years) had 7258 nodules at baseline CT screening.
1741 participants (51.3%) had one nodule,
802 (23.6%) had two nodules,
356 (10.5%) had three nodules,
193 (5.7%) had four nodules and 300 (9.9%) had more than four nodules.
Figure 1 shows the distribution of the nodule count per participant.
62 nodules were confirmed to be malignant in the immediate period after the baseline screening CT.
The percentage of participants with lung cancer was 1.6% in case one nodule was present,
2.1% in participants with two nodules,
1.7% with three nodules,
3.6% with four nodules and 1.7% in case of more than four nodules (Figure 2).
A significant difference was found in lung cancer probability for group of 1-4 nodules (1.8%) compared to five or more nodules (1.6%,
Of the malignant nodules,
57/62 (91.9%) were found in participants with less than five nodules detected (Table 1).
In nearly all lung cancer cases (60/62,
the malignant nodule had the largest volume of all detected nodules per participant.
On population basis,
the mean nodule count in participants with only benign nodules was 2.2% compared to 2.7% in participants with at least one malignant nodule (p = NS).