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Head and neck, Nuclear medicine, PET-CT, Outcomes analysis
G. Feliciani, F. Fioroni, E. Grassi, M. Bertolini, A. Nitrosi, P. Ciammella, A. Versari, C. Iotti, M. Iori; Reggio Emilia/IT
Methods and materials
• NEMA IEC Body Phantom Set™ (Data Spectrum Corporation,
NC) see fig.1.
• Spheres of different radius were equally filled varying Target/Background(TB) activity concentration of 18F-FDG and scanned for different acquisition times
• PET images were reconstructed on a 256×256 image matrix with 40 equivalent iteration and varying smoothing filter width
• Spheres contour segmentation was performed on dedicated Workstations using a 40% SUVMAX threshold algorithm
• A dataset of 121 patients with HNSCC,
who underwent pre-treatment 18F-FDG PET/CT and completed concurrent radio-chemotherapy,
was used to score prognostic significance of texture analysis
• All patients were followed up at least 24mo or until death
• Textural features were extracted from VOIs contoured on the pretreatment18F-FDG PET/CT making use of the 40% SUVMAX algorithm mentioned above