Adverse reactions to intravenous contrast media (CM) agents are uncommon, although relevant due to the growing number of radiologic examinations that use iodinated contrast agents [1]. Reaction may be patient related and risks of acute adverse reaction is usually searched before administration. Reactions are classified according to guidelines in non renal, renal and miscellaneous [2]. Most common non-renal reactions are acute allergic reactions that are usually classified in mild, moderate and severe. In order to reduce acute allergic reactions patient- risk factors are deeply screened...

We retrospectively studied number of adverse contrast reaction in MDCT in our population of 43680 patients submitted to MDCT with administration of CM 73 patients, who had an adverse allergic reaction to iodinated CM, were analysed from January 2011 to May 2014; 1 patient (0,002%) had a severe allergic reaction requiring resuscitation manoeuvre and was exclude from the sample. 72 (0,164%) patients had a mild or moderate adverse reactions (Fig. 1). Symptoms referred by patients or annotated in patient flow chart are listed in Fig....

MDCT with contrast because was considered clinically necessary and repeated after a premedication according with ESUR guidelines (prednisolone 30 mg orally given 12 and 2 hours before contrast medium), in 20 patients (27,39%) using a different contrast compounds. No allergic adverse effect was observed in this population.

Recommended premedication regimen and change of contrast compound may increase safety of administration and reduce allergic reactions in case of repeated MDCT with CM and history of previous mild or moderate allergic reactions.

1. General adverse reactions to contrast agents. Classification and general concepts (2014).. Aguilar García JJ, Parada Blázquez MJ, Vargas Serrano B, Rodríguez Romero R. Radiologia; 56:3-11. doi: 10.1016/j.rx.2014.06.004. 2. ESUR Guidelines on contrast media vs 8.1 (2014). http://www.esur.org/guidelines. 3. Breakthrough reactions of iodinated and gadolinium contrast media after oral steroid premedication protocol (2014). Jingu A, Fukuda J, Taketomi-Takahashi A, Tsushima Y. BMC Med Imaging. 6;14:34. doi: 10.1186/1471-2342-14-34.