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Keywords:
Liver, MR, Computer Applications-General, Haematologic diseases
Authors:
A. Casaleggio, C. Conforti, F. Paparo, L. Bacigalupo, D. Zefiro, C. M. viberti, G. Forni, G. A. Rollandi; Genoa/IT
DOI:
10.1594/ecr2015/C-1580
Methods and materials
This retrospective observational study was performed on 15 thalassemic patients undergoing MRI examinations under chelation therapy and about fifty FerriScanTM-T2 and T2* MRI examinations were performed and compared.
Exams were done with a 1.5T General Electric Hdx scanner using an eight-element cardiac/torso coil.
Breath-hold T2*-MRI measurements were performed and the whole liver was scanned employing a multi-echo gradient echo sequence.
T2-MRI measurements were performed with a multislice single spin-echo pulse sequence according to the FerriScanTM protocol and the images acquired were sent via a secure electronic link to the FerriScanTM central for processing.
The LICdw reports produced were considered as a reference standard.
Three commercial software programs performing T2* relaxometry were used for the LIC estimation:
•Quanta Hematology (Camelot Biomedical Systems,
Genoa,
Italy) [Figure 2,3,4,5];
•CMRTools (Cardiovascular Imaging Solutions,
London,
UK) [Figure 6];
•FuncTool (General Electric Medical Systems,
Milwaukee,
WI) [Figure 7,8,9].
To perform a direct comparison with the average LICdw of the FerriScanTM report,
a radiologist with 7 year experience in MRI (FP) selected the slice on multi-echo gradient images which was corresponding to the slice shown in the FerriScanTM report.
Correlations among LICdw measurements were subjected to linear regression analysis and the regression coefficient R2 was used to evaluate the correlation between the techniques; the software were also compared using Bland–Altman plots.