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Keywords:
Contrast agent-intravenous, CT, Molecular imaging, Biological effects
Authors:
I. Willekens, N. Buls, T. Lahoutte, F. Verhelle, J. de Mey; Brussels/BE
DOI:
10.1594/ecr2015/C-2448
Aims and objectives
Advanced imaging methods can play an increasing role in preclinical studies.
Microcomputed tomography (Micro-CT) offers excellent resolution,
but has been restricted to the analysis of x-ray attenuating tissues like bone.
The soft tissue contrast resolution is insufficient for detailed analysis.
To improve the visualization of abdominal organs,
exogenous contrast agents can be used.
In combination with an appropriate contrast agent,
micro-CT imaging can be an interesting tool in serial imaging of small animal models.
Gold has higher absorption than iodine,
archiving better contrast.
Nanoparticles clear the blood more slowly,
permitting a longer blood residence time. The aim of our study was to characterize the kinetics of gold nanoparticle-based contrast agents for preclinical imaging.