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Keywords:
Liver, Ultrasound, Elastography, Diagnostic procedure
Authors:
G. Ferraioli, L. Maiocchi, R. Lissandrin, C. Tinelli, C. Filice; Pavia/IT
DOI:
10.1594/ecr2016/B-1085
Results
Ninety-six patients [62 males,
34 females; mean age,
56.6 (12.1) years] were studied.
Ninety-one patients were affected by chronic hepatitis C,
fifteen of whom were coinfected with HIV; three patients were HIV-monoinfected; two patients were affected by non alcoholic fatty liver disease.
Thirty-eight individuals were in F0-F1 stage,
13 in F2 stage,
10 in F3 stage,
and 35 in F4 stage.
The optimal cutoff of QElaXto® for staging significant fibrosis (F≥2) was 8.8 kPa [sensitivity,
87.9% (95%CI: 76.7-95.0); specificity,
97.4% (95%CI: 86.2-99.9); LR+,
33.4 (95%CI: 4.8-231.7); LR-,
0.12 (95%CI: 0.06-0.29)].
For staging liver cirrhosis (F=4) the optimal cutoff was 10.6 kPa [sensitivity,
86.7% (95%CI: 73.2 - 94.9); specificity,
98.0% (95%CI: 89.6 - 100.0); LR+,
44.2 (95%CI: 6.3 - 308.8); LR-,
0.14 (95%CI: 0.06 - 0.3].
AUROC calculations showed values of 0.98 (95% CI: 0.96-1.00) for F≥2 and 0.97 (95% CI: 0.95-1.00) for F=4 (Figure 2 and Figure 3).