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Keywords:
Abdomen, Liver, MR physics, MR, MR-Diffusion/Perfusion, Diagnostic procedure, Imaging sequences, Staging, Cirrhosis, Metabolic disorders
Authors:
L. CUMINAL1, O. Beuf1, B. Leporq2, J. Dumortier1, S. Gaillard1, V. Hervieu1, O. Guillaud1, A. MULLER1, P.-J. Valette1; 1Lyon/FR, 2Villeurbanne/FR
DOI:
10.1594/ecr2016/B-1088
Purpose
The incidence of non-alcoholic fatty liver disease (NAFLD) has increased considerably over the last 10 years to become the first cause of chronic liver diseases in developed countries. Nonalcoholic steatohepatitis (NASH) is characterized in additition to steatosis by inflammation and hepatocyt injury leading to fibrosis.
It's important to make an early diagnosis because the major complications of this disease are lifethreatening and include portal hypertension,
liver insufficiency, and hepatocellular carcinoma.
Liver biopsy remains the gold standard for liver fat quantification as well as diagnosing and staging hepatic fibrosis.
Morbidity and mortality and other limitations such as inter observer variability,
sampling errors and increasing health care cost make this method unsuitable for a clinical monitoring.
There is therefore a need to develop non-invasive methods for the diagnosis and monitoring of these liver diseases.
The purpose of HEPATOMAP study was to exploit a fast and accurate exam combining several validated MR techniques in previous studies to generate multiple quantitative parameters maps for hepatic fat content,
liver fibrosis grading and allow to differentiate pure steatosis of steatohepatitis compared to the biopsy data.