Tumour volume analysis TVA vs RECIST

This poster is published under an open license. Please read the disclaimer for further details.

Congress:

ECR 2016

Poster Number:

B-1275

Type:

Scientific Paper

Keywords:

Breast, Oncology, Ultrasound, Chemotherapy, Cancer

Authors:

A. Gordon, J. Morden, A. K. Lim, S. Cleator; London/UK

DOI:

10.1594/ecr2016/B-1275

DOI-Link:

https://dx.doi.org/10.1594/ecr2016/B-1275

Fig. 1: Diagram illustrating the effects on the differences of the lesser 2 axes on the...

Fig. 2: Bar chart of tumour recist% change versus TVA% change (sorted by TVA change)

Fig. 3: Scatter plot of RECIST %change vs TVA %change

Results

Twenty four patients responded to treatment and

regressed by diameter and/or volume ( C n=10

versus E n=14 ). No statistically significant

difference was seen in the magnitude of response

between treatment groups, when using either

RECIST or TVA. Median percentage regression

was -34% ( IQR -44- --25.5 ) by diameter RECIST

and -73% ( IQR -85.5- --42.5 ) by volume TVA. P<0.0001

Of the two tumours that enlarged

by TVA alone the Tumour Doubling Times

were +135 and +337 days. The 24 tumours

that regressed had a Complete Response

Time range -23- -1005 days. Two cases progressed

>20% volume and were Stable Disease ( SD ) by

RECIST. Five were SD by RECIST but responded

>30% volume by TVA.