To Identify the differents MRI sequences useful for the exploration of brain metabolic affections.
To present an analysis procedure of leukodystrophies diagnosis,
based on the MRI sequence and spectroscopy finding.
Leukodystrophies are white matter disorders that are genetic in nature.
In the young,
they represent an important cause of progressive neurological disability.
They are frequently recognized on MRI,
but their identification remains a challenge.
Their diagnosis is important for prognostication,
palliative and experimental treatment,
as well as family screening.
The diagnostic strategy rests upon clinical clues and MRI patterns,
complemented by appropriately selected electrophysiological and laboratory testing.
Findings and procedure details
encompass a wide spectrum of inherited neurodegenerative disorders affecting the integrity of myelin in the brain and peripheral nerves.
Most of these disorders fall into one of three categories:
o Lysosomal storage diseases
o Peroxisomal disorders
o Diseases caused by mitochondrial dysfunction
Each leukodystrophy has distinctive clinical,
and radiologic features.
Magnetic resonance (MR) imaging has be-come the primary imaging modality in patients with leukodystrophy and plays an important role in the identification,
and characterization of underlying white matter...
White matter disorders in children are complex.MR imaging is highly sensitive in determining the presence and assessing the severity of underlying white matter abnormalities in patients with leukodystrophy.
Although the findings are often non-specific,
systematic analysis of the finer details of disease involvement may permit a narrower differential diagnosiS
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