Aims and objectives
To determine the effectiveness,
in a post-market clinical study,
of MARIA (Micrima Ltd,
Bristol UK) – a non-ionising,
non-compressing whole-breast scanning system utilising radiowaves – in symptomatic breast care clinics.
this work considers patients whose breast density has been graded ‘c’ or ‘d’ on the BIRADS scale and for whom a diagnosis of cancer had been determined,
as verified by biopsy and subsequent histologic analysis.
Unlike x-ray mammography,
radio-wave imaging does not suffer from impaired detection ability in dense breast tissue (1).
Methods and materials
Patients attending symptomatic clinics at three sites were identified by clinicians as having a palpable lump.
Following informed consent,
eligible patients underwent this prone imaging technique.
The bilateral reconstructed 3D images were correlated with clinical information and other imaging studies including ultrasound and/ or mammography and,
core biopsy results to determine sensitivity scores.
[Ethics approval (Yorkshire & The Humber and South Yorkshire REC 15/YH/0084,
Description of the procedure:
Where possible patients had an ultrasound examination and a mammogram as well...
Of 28 cases evaluated that were graded either BIRAD c or d for breast density and where biopsy confirmed a diagnosis of cancer,
a sensitivity of 86% (24/28) was obtained for lesion detection using MARIA (mean age 54.5,
age range 32-80).
Two case studies are presented which illustrate the imaging results obtained from MARIA™ for cases where the mammogram read is either ill-defined (figure 3) or concerns a mammographically-occult lesion (figure 4).
Initial results indicate the potential that the MARIA system offers as a well-tolerated,
non-ionising imaging modality.
MARIA has been shown to be effective at detecting cancers in younger,
pre-menopausal women with dense breasts.
MARIA may contribute to overcoming some of the challenges posed by trying to optimise the balance between benefit and harm of screening in women of younger age or who otherwise exhibit dense breast tissue.
The results of this post-market study are very encouraging and we are continuing to evaluate this exciting novel...
Dr Nick Ridley,
Great Western Hospitals NHS Foundation Trust,
SN3 6BB email@example.com
Dr Mike Shere,
Bristol Breast Care Centre,
Bristol BS10 5NB firstname.lastname@example.org
Prof Iain Lyburn,
Thirlestaine Breast Center,
GL52 7AS email@example.com
Dr Peter Bannister,
One Glass Wharf,
BS2 0EL firstname.lastname@example.org
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Numerical investigation of breast tumour detection using.
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Proceedings of the...