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MR physics, Pelvis, Computer applications, MR, MR-Diffusion/Perfusion, Experimental, Physics, Experimental investigations, Technical aspects, Cancer, Image verification, Neoplasia
N. Papanikolaou1, G. C. Manikis2, I. Santiago1, K. Marias2, C. Matos1; 1Lisbon/PT, 2Heraklion/GR
Methods and materials
A multi-b value diffusion sequence,
optimized for the quantification of diffusion imaging biomarkers was acquired twice (test-retest scheme) in the same imaging session using a 1.5T MR Scanner (Philips,
Ingenia) in eighteen patients with locally confined prostate cancer.
The diffusion sequence comprised 7 b values (0,
1000 and 1500 s/mm2) and 4 different models including Gaussian mono-exponential (gm),
Gaussian bi-exponential (gb),
non-Gaussian mono-exponential (ngm) and non-Gaussian bi-exponential (ngb) were applied to quantify the following diffusion biomarkers: ADC,
Kngb, Kngm , and Dngm.
Variation coefficients (CV) were calculated for all diffusion biomarkers.