Keywords:
Thorax, Lung, Computer applications, CT, CT-High Resolution, CT-Quantitative, Computer Applications-Detection, diagnosis, Computer Applications-3D, Segmentation, Tissue characterisation, Chronic obstructive airways disease
Authors:
R. Sanz-Requena, M. L. Peris Pérez, M. P. Calvillo, G. García-Martí, L. Marti-Bonmati; Valencia/ES
DOI:
10.1594/ecr2018/C-0451
Aims and objectives
Lung emphysema is common in chronic obstructive pulmonary disease (COPD).
Pulmonary functional tests (PFT) are currently used for the clinical diagnosis of emphysema.
However,
these tests show a high variability and are limited for the detection of early stage COPD.
Conversely,
computed tomography (CT) can be used to detect and quantify emphysema with very high accuracy.
It is hypothesized that not only the total volume but also de distribution of emphysema has an impact in the pulmonary function of the patient.
It has been demonstrated that the amount of emphysema is inversely related to pulmonary function,
but it is still necessary to investigate the influence of the distribution.
The amount of lung emphysema is inversely related to the diffusing capacity of lung carbon monoxide (DLCO).
The aim of this work is to quantify both peripheral and central emphysema and establish the relationship with DLCO/VA (DLCO normalized by alveolar volume).