Aims and objectives
Diffusion-weighted MR imaging (DWI) can be applied to evaluate kidneys in many clinical aspects,
assessment of focal renal masses,
renal insufficiency or chronic kidney disease (CKD),
renal artery stenosis as well as evaluation in transplanted kidneys [1-2].
For assessment of chronic kidney disease,
DWI has shown to be an emerging technique to evaluate renal function,
regarding the principle of Brownian motion of water molecules within tissues .
The quantitative diffusion measurement is performed using apparent diffusion coefficient (ADC),
which is calculated...
Methods and materials
The retrospective study included 216 patients with chronic kidney disease (CKD) who examined abdominal MRI for different reasons and had the information of eGFR within four weeks from imaging date between January 2015 and January 2016.
The eGFR was calculated using CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration equation) .
The data including demographic information,
and laboratory findings were obtained from the medical records of the patients.
Patients were classified into four grouped stages of CKD according to eGFR values adapted from the K/DOQI...
The study comprised of 216 patients with CKD (132 men,
84 women; aged 20 to 88 years and mean age was 62.39 years) which were 72 (33.3%),
46 (21.3%) and 16 (7.4%) patients in grouped stage 1,
3 and 4,
Correlation between ADC values and eGFR
The study showed a significant linear correlation between the ADC values and eGFR in the patients with CKD (r=0.254,
p<0.001) (Table 1) (Figure 2).
Analysis of ADC values at different grouped stages of CKD
In our study,
we performed MRI by using 3-T scanners and diffusion gradient b values of 0,
500 and 750 s/mm2,
which was different from the previous studies [2-5].
We evaluated the patients with CKD and demonstrated a weak linear correlation between renal ADC values and eGFR.
We also found the significant different between mean ADC values in CKD patients with moderate-severe reduced renal function (eGFR,
< 60 mL/min/1.73m2) versus those with normal or mild reduced renal function (eGFR,
≥ 60 mL/min/1.73m2).
Division of Diagnostic Radiology,
Department of Radiology,
Faculty of Medicine Siriraj Hospital Mahidol University- Bangkok,
Address: 2 Wanglang road,
Phone: + 6624197078
De Keyzer F.
Diffusion-weighted MR imaging of native and transplanted kidneys.
Measurement of the apparent diffusion coefficient in diffuse renal disease by diffusion-weighted echo-planar MR imaging.
J Magn Reson Imaging 1999;9:832–37.
Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study.
Eur J Radiol 2014;83:756-62.