Aims and objectives
Liver transplantation is the treatment of choice for end-stage chronic disease due to the hepatitis C virus (HCV) and for selected patients with hepatocellular carcinoma who are not candidates for surgical resection (1).
the recurrence of HCV infection is the rule in viremic patients at the time of transplantation (2).
HCV relapse on the graft is the main cause of HCV infection in patients who undergo a liver transplant for cirrhosis due to HCV (3).
The most important events that influence...
Methods and materials
A prospective longitudinal study was carried out from September 2012 to February 2016 in which 60 consecutive recipients of liver transplant for any etiology were included in our hospital.
we selected the 15 patients who presented reinfection of the graft by HCV during the first year after the transplant and who received treatment with the new antivirals.
The hospital ethics committee considered that the approaches were correct and gave its approval to do so.
The patients were informed and gave their consent.
Of the 14 patients included in the analysis,
10 were male and 4 were female,
with a mean age of 52.8 years (standard deviation of 8.2 years,
minimum 36 years and maximum 65 years).
The reason for the transplant was hepatocellular carcinoma in 8 patients and HCV induced end stage disease in 6.
All patients achieved a sustained viral response 3 months after treatment.
The values obtained in the two determinations of elastography performed on each patient are shown in Table 2.
The aim of this study was to evaluate the changes in liver shear wave velocity values obtained by Acoustic Radiation Force Impulse (ARFI) elastography after antiviral treatment in patients with orthotopic liver transplants and hepatitis C virus (HCV) infection with relapse after transplantation.
The increased shear wave velocity in elastography,
as well as the analytical data,
is not specific for liver involvement due to viral recurrence,
but it offers additional information with a different foundation from that of the analytical one: a physical,
Hospital Universitario Puerta de Hierro Majadahonda
AASLD practice guidelines: Evaluation of the patient for liver transplantation.
1 de junio de 2005;41(6):1407-32.
Sofosbuvir-Based Antiviral Therapy Is Highly Effective In Recurrent Hepatitis C in Liver Transplant Recipients: Canadian Multicenter Â«Real-LifeÂ» Experience.
mayo de 2016;100(5):1059-65.
Monitoring the Natural Evolution and Response to Treatment of Post Liver Transplant Recurrent Hepatitis...