Aims and objectives
As is known,
microcalcification is one of the most pathognomonic symptoms of breast cancer in situ .
The "gold standard" for the identification of breast microcalcifications is digital mammography.
It allows detection of microcalcifications,
assessment of its distribution,
location and size.
biopsies in case of microcalcifications are performed under the X-ray control.
the search for a safer and more convenient way of visualizing microcalcifications continues,
according to some authors,
has the greatest potential in diagnosing of such lesions.
Methods and materials
This study was a prospective clinical trial conducted from January 2016 to July 2016.
A total of 52 consecutive female patients [50.4-60.0 (mean 54.5±2.5) years of age],
who attended Astana City Oncologic Center within the framework of the Kazakhstan mammography screening program and fulfilled the inclusion criteria: voluntary participation in the breast cancer screening program; no history of previous breast cancer; screening mammography findings rated as BI-RADS 4; the presence of visible on mammogram microcalcifications without associated breast mass; and available histopathology as a reference...
Concerning the distribution of the microcalcifications,
in 29 cases (56%) they were classified as clustered,
in 13 cases (25%) as linear (Figure 1),
and in 10 cases (19%) as segmental (Figure 2).
The number of microcalcifications per squared centimeter: below 10 per sq.cm – 24 (46%),
10-25 microcalcifications per sq.cm- 19 cases (37%),
and more than 25 microcalcification per sq.cm -9 cases (17%) (Table 1)
Of 52 screening women examined,
12 (23%) were diagnosed with breast malignancy (eight invasive cancers,
and 40 (77%)...
In screening patients with BI-RADS 4 microcalcifications the sensitivity of the “MicroPure” technology was relatively low from 37% to 68% for different types of microcalcifications.
These results do not contradict the results of the previous studies,
which reported that only 23 to 25% of the microcalcifications can be detected by “MicroPure”[8,9].
Although the sensitivity of the technology was low,
its specificity for segmental and linear types of microcalcifications in this study was 100%.
The relatively low sensitivity of the “MicroPure” in the detection of microcalcifications...
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