Aims and objectives
Arteriosclerosis is hardening and thickening of the arteries causing reduced dampening of the blood pressure fluctuations throughout the cardiac cycle.
As a result,
the systolic blood pressure is elevated and perfusion during diastole is reduced.
This causesend organ damage affecting primarily heart,
brain and kidneys.
Reduced elasticity increases load on the heart leading to left ventricular hypertrophy.
Carotid-femoral pulse wave velocity (PWV) reflects arterial stiffness and has been proven to correlate well with cardiovascular mortality and morbidity.
It is a good predictor in evaluation of...
Methods and materials
This study is based on three cohorts.
Tayside Screening for Cardiovascular Events (TASCFORCE) study comprised of 1,528 participants who have undergone WB-MRA.
It enrolled low to intermediate risk participants free from cardiovascular disease.
It was used to derive a carotid-femoral artery length formula.
The arterial length from the right common carotid artery bifurcation to the aortic arch and from aortic arch to bifurcation of the right common femoral artery were measured by one of 4 image analysts in Carestream PACS software (Client Suite Version 10.1...
The right carotid femoral path length formula after backward linear regression was:
100.36+(0.70×Age[years]) + (137.81×Height[m]) + (0.51×Weight[kg]) - (0.18×heart rate [bpm]) + (46.25 [if female],53.89 [if male])
After excluding those with missing data required for the formula or for PWV calculation the final analysis included 929 SUMMIT participants.
There were significant differences between PWV between three European sites (Dundee,
Exeter and Pisa,
participants >62 years of age) using both PWVSUMM (F-test 19.4,
p<0.001) and PWVMRA (F-test 17.4,
The strong determinants of PWV (age,
Our automatic distance calculation formula derived from routinely obtained data reduces intercentre differences in PWV measurements in comparison with PWV calculated from tape measurements.It can improve standardisation of the PWV calculation methodology which currently varies across different centres.
de Backer TLM,
van Bortel LM.
Carotid to femoral pulse wave velocity: a comparison of real travelled aortic path lengths determined by MRI and superficial measurements.
Journal of hypertension.
Van Bortel LM,
De Backer T,
Expert consensus document on the measurement of aortic stiffness in daily...