Keywords:
Toxicity, Tissue characterisation, Image verification, Experimental investigations, Efficacy studies, Ultrasound, Ultrasound physics, Musculoskeletal soft tissue
Authors:
A. André, J. Figueiredo, G. Fontes Ribeiro, N. Osório, A. Armando, C. A. Fontes Ribeiro, P. Tavares; Coimbra/PT
DOI:
10.1594/ecr2018/C-2972
Aims and objectives
To evaluate the muscle macroscopically some measurements is important to do,
pennate angle and fascicle length are determinants of muscle strength,
the thickness is important to evaluate state of atrophy or hypertrophy.
The ecogenicithy evaluate the fat infiltration in atrophy situation [1-2].
Statin is the name given to the group of drugs to help to reduce cholesterol levels and more prescribed in the world to preven dyslipidemia [3].
It is well known that statins can promote myopathy which can be slight,
moderate or severe (rhabdomyolysis).
The biomarker that can influence the state of the muscle is creatine phosphokinase (CPK),
this can change with gender,
age,
muscular mass and physical activity [3]
Factors that influence the increase of CK are exercise intensity,
if it exceeds the metabolic capacity alterations that origin CPK release to the blood circulation happen [5] and the sarcomere degradation,
higher the degradation higher the CPK values which may reflect necrosis [4-6].
This study aimed to evaluate and analyze macroscopically muscle structures in patients with hypercholesterolemia,
to interpreting the pathophysiological mechanisms produced by statins inducing myotoxicity.
The objectives were verify if the ultrasound is an image modality with sensitivity and acuity for muscular evaluation in the group that intake statins with muscular alterations