Anatomy, MR, Imaging sequences, Dementia
E. Tuzzi, G. E. Hagberg, D. Balla, J. Loureiro, M. Neumann, C. Laske, R. Pohmann, K. Scheffler; Tübingen/DE
Aims and objectives
Alzheimer’s Disease (AD) is the most common cause of dementia worldwide.
So far univocal diagnosis of AD is only achieved by postmortem histology.
Beta-Amyloid plaques are known to be classical hallmarks of the post mortem Alzheimer´s Disease brain.
Beta-Amyloid deposits are currently detected by PiB-PET imaging,
which only provides a coarse localization of the affected areas.
On the other hand,
ultra-high field (UHF) MRI offers a potential non-invasive means to diagnose AD in early stage by allowing imaging at very high spatial resolution.
This study aimed to investigate the capability to detect Beta-Amyloid plaques in-vivo,
using ultra-high field,
by combining R2* and quantitative susceptibility mapping (QSM) in-vivo and ex-vivo,