STE technology provides a new method for quantifying the elasticity information of the liver tissue for grading fibrosis in CLD. It is a non-invasive technique, easy to use after proper training, and without any discomfort to the patient. An STE measurement of liver stiffness within the normal range can rule out significant liver fibrosis if in agreement with the clinical and laboratory data. Knowledge of the etiology of the CLD of a specific patient (HBV, HCV, ALD, NASH) and the degree of necro-inflammation is a prerequisite, since different cut-off values apply per etiology and per grade of necro-inflammatory process.