Aims and objectives
The aim of our study was to evaluate the role of ADC and IVIM derived quantitative parameters in the characterization of solid focal liver lesions using a volumetric approach.
Methods and materials
Between November 2017 and February 2018,
100 patients were retrospectively collected with suspicious focal solid hepatic lesions that underwent routine MRI of the upper abdomen.
The inclusion criteria were:
presence of solid FLLs;
diameter lesion > 1cm;
not previously treated FLLs before MRI
histopathological confirmation after surgery or biopsy (in case of metastasis);
at least four follow up for B FLLs with typical imaging feature of FNH.
Patients were scanned on a 1,5 T MR scanner (MAGNETOM Avanto,
The final study population consisted of 100 patients (female: 45,
male: 55) with a 104 lesions (77 malignant and 27 benign) (Table 1) and with a total 34 hypervascular malignant FLLs and 43 hypovascular malignat FLLs respectively.
The means of each ADC and IVIM derived quantitative parameters are reported in Table 2 and 3 (Fig 5 and Fig 6),
in Table 4 (Fig 7)are illustrated theresults of ROC analysis.
The ADC mean and ADC median were significantly different between benign VS malignant lesions...
ADC values of solid FLLs were significantly higher than their D value,
which confirms the influence of tissue microperfusion on the calculation of ADC.
We also found that D showed better diagnostic performance than ADC in differentiating malignant from benign FLLs.
IVIM-DWI derived perfusion parameters were significantly higher in hypervascular malignant FLLs than in hypovascular malignat FLLs.
we may suggest a correlation between perfusion parameters of the IVIM model representing microscopic perfusion characteristics of tissue and the classic perfusion pattern on dynamic imaging,
Puglia: Department of Radiology,
Santa Maria delle Grazie Hospital,
Bali: Department of Radiology,
Université Libre de Bruxelles (Belgium).
Picchia: Department of Radiology,
University "La Sapienza" I.C.O.T Hospital,
Orton: CRUK Cancer Imaging Centre,
Institute of Cancer Research (Sutton UK)
Doran: CRUK Cancer Imaging Centre,
Institute of Cancer Research (Sutton UK).
Feiweier: Siemens AG,
Koh: Department of Radiology,
The Royal Marsden Hospital (Sutton UK)
Morana: Department of Radiology,
Ca'Foncello Regional Hospital...
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