Learning objectives
In the current scenario,
PSMA labelled with radioisotopes 18F,68Ga,
99mTc and 177Lu is an exciting tool for diagnosis as well as for therapy.
The purpose of this study is to review 68Ga-PSMA,
18F-PSMA and 99mTc-PSMA around their feasibility,
production and chemistry to find which can be considered as a gold standard for Prostate cancer imaging.
Background
Prostate cancer is the second leading cause of death in the United States of America and all over the world is one of threat for the men health.
As per the American Cancer Society website (2018) 1 man in 9 has the probability of getting diagnosed with prostate cancer in their lifetime.
Websites also state that 1 out of 41 man dies due to prostate cancer every year.
As per The Surveillance,
Epidemiology,
and End Results (SEER) data (2018); about 164,690 new cases of prostate...
Findings and procedure details
Nowadays PSMA PET-CT scanning is showing promising results for detection and staging of Prostate cancer.68Ga- PSMA and 18F-PSMA are commonly used for scanning.
Both have their pros and cons.
The recent inclusion of 99mTc-PSMA has created the opportunity of doing a scan with the help of SPECT-CT.
Currently,
to label PSMA for diagnostic purpose,
three are three radionuclides available,
68Ga,
18F and 99mTc with their pros and cons.
Radioisotope Gallium-68 is a choice of isotope for labelling with PSMA due to few specific properties; which...
Conclusion
All these Radiopharmaceuticals have their advantage,
and disadvantage; their selection should be made based on the requirements and feasibilities.
Personal information
American cancer society.
(2016) American Cancer Society Recommendations for Prostate Cancer Early Detection.
Retrieved from https://www.cancer.org/cancer/prostate-cancer/early-detection/acs-recommendations.html
Bouchelouche,
K.,
& Capala,
J.
(2010).
'Image and treat': an individualized approach to urological tumors — current opinion in oncology,
22(3),
274-80.
Bouchelouche,
K.,
& Choyke,
P.
L.
(2016).
Prostate-specific membrane antigen positron emission tomography in prostate cancer: a step toward personalized medicine.
Current opinion in oncology,
28(3),
216-21.
Cardinale,
J.,
Martin,
R.,
Remde,
Y.,
Schafer,
M.,
Hienzsch,
A.,
Hubner,
S.,
.
.
.
Kopka,
K.
(2017).
Procedures for...
References
American cancer society.
(2016) American Cancer Society Recommendations for Prostate Cancer Early Detection.
Retrieved from https://www.cancer.org/cancer/prostate-cancer/early-detection/acs-recommendations.html
Bouchelouche,
K.,
& Capala,
J.
(2010).
'Image and treat': an individualized approach to urological tumors — current opinion in oncology,
22(3),
274-80.
Bouchelouche,
K.,
& Choyke,
P.
L.
(2016).
Prostate-specific membrane antigen positron emission tomography in prostate cancer: a step toward personalized medicine.
Current opinion in oncology,
28(3),
216-21.
Cardinale,
J.,
Martin,
R.,
Remde,
Y.,
Schafer,
M.,
Hienzsch,
A.,
Hubner,
S.,
.
.
.
Kopka,
K.
(2017).
Procedures for...