Aims and objectives
Mammography is a fundamental part of breast cancer diagnosis.
The images hold crucial information but their full potential is not yet used in clinical practice.
In addition,
pathological outcome parameters such as tumour size,
histologic tumour type,
molecular receptor status,
and axillary lymph node involvement are essential in clinical decision-making.
Previous studies have investigated how mammographic tumour features correlate to pathological outcome and survival and they have shown that certain tumour features may harbour prognostic information.
For example,
tumours with fine linear branching calcifications (casting-type)...
Methods and materials
Data was collected from the Malmö Diet and Cancer Study (MDCS),
a population-based prospective cohort enrolling 28098 patients from 1991 to 1996,
of whom 17035 were women6.
At baseline examination anthropometric variables were collected and a comprehensive questionnaire filled in7.
Participants were thereafter continuously followed up8.
In the female population 1242 women were diagnosed with breast cancer from 1991 to 2014.
After exclusion of cancer in situ (n = 105) and bilateral breast tumours (n = 21) a total of 1116 women with invasive breast...
Results
The distribution of ER,
PgR and HER2 status across mammographic features is shown in table 1.
Spiculated tumours were more often ER positive than ER negative compared to distinct masses,
ORadj5.6 (CI 3.0-10.4).
The spiculated tumours were likewise more often PgR positive than PgR negative compared to distinct masses,
ORadj1.8 (CI 1.2-2.5).
Ill-defined masses and tumours presenting with calcifications were slightly more often HER2 positive compared to the other tumour features in terms of distribution.
However,
we found no statistically significant difference in multivariate analyses...
Conclusion
In this study,
we have shown that spiculated tumours were significantly more likely to be ER and PgR positive than negative as compared to distinct masses.
These findings may partly explain the favourable prognosis of spiculated tumours as compared to other tumour features previously described in the literature3.
A majority of the spiculated tumours were of luminal A-like subtype,
a subtype known for its low breast cancer mortality10.
Further,
we have shown that the molecular breast cancer subtypes differed significantly in relation to mammographic features....
Personal information
Li Sturesdotter
MD
Medical Radiology Unit,
Dept of Translational Medicine,
Lund University Dept of Medical Imaging and Physiology,
Skåne University Hospital Malmö,
Sweden
[email protected]
Hanna Sartor
MD,
PhD
Medical Radiology Unit,
Dept of Translational Medicine,
Lund University Dept of Medical Imaging and Physiology,
Skåne University Hospital Lund,
Sweden
[email protected]
Malte Sandsveden
MD
Department of Surgery,
Skåne University Hospital Malmö,
Lund University,
Malmö,
Sweden
[email protected]
Kristin Johnson
MD
Medical Radiology Unit,
Dept of Translational Medicine,
Lund University Dept of Medical Imaging and Physiology,
Skåne University Hospital...
References
Tabar L,
Chen HH,
Duffy SW,
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A novel method for prediction of long-term outcome of women with T1a,
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Alexander MC,
Yankaskas BC,
Biesemier KW.
Association of stellate mammographic pattern with survival in small invasive breast tumors.
AJR.
American journal of roentgenology.2006;187(1):29-37.
Evans AJ,
Pinder SE,
James JJ,
Ellis IO,
Cornford E.
Is mammographic spiculation an independent,
good prognostic factor in screening-detected invasive breast cancer? AJR.
American journal of roentgenology.2006;187(5):1377-1380.
Killelea...