Keywords:
Pathology, Epidemiology, Cancer, Statistics, Screening, Outcomes analysis, Mammography, Oncology, Breast
Authors:
L. Sturesdotter1, H. Sartor2, M. Sandsveden1, K. Johnson2, S. Zackrisson1; 1Malmö/SE, 2Lund/SE
DOI:
10.26044/ecr2019/C-1178
Conclusion
In this study,
we have shown that spiculated tumours were significantly more likely to be ER and PgR positive than negative as compared to distinct masses.
These findings may partly explain the favourable prognosis of spiculated tumours as compared to other tumour features previously described in the literature3.
A majority of the spiculated tumours were of luminal A-like subtype,
a subtype known for its low breast cancer mortality10.
Further,
we have shown that the molecular breast cancer subtypes differed significantly in relation to mammographic features.
Multivariate analyses are planned to study this matter in greater detail.
As an example,
in our material a large proportion of the spiculated tumours were luminal A-like while only a few were TNBC.
Of the tumours presenting as distinct mass just less than half were luminal A-like while a larger proportion,
17.2 %,
were TNBC.
This is a trend consistent with results from a previous study were TNBC was found to be associated with a mammographic mass4.
Associations between mammographic features of breast tumours and their IHC profile and molecular subtype may aid in defining tumour aggressiveness at an earlier stage in breast cancer diagnosis and care.
This can potentially contribute to a more personalized breast cancer treatment in the future.