Keywords:
Pathology, Epidemiology, Cancer, Statistics, Screening, Outcomes analysis, Mammography, Oncology, Breast
Authors:
L. Sturesdotter1, H. Sartor2, M. Sandsveden1, K. Johnson2, S. Zackrisson1; 1Malmö/SE, 2Lund/SE
DOI:
10.26044/ecr2019/C-1178
Results
The distribution of ER,
PgR and HER2 status across mammographic features is shown in table 1.
Spiculated tumours were more often ER positive than ER negative compared to distinct masses,
ORadj5.6 (CI 3.0-10.4).
The spiculated tumours were likewise more often PgR positive than PgR negative compared to distinct masses,
ORadj1.8 (CI 1.2-2.5).
Ill-defined masses and tumours presenting with calcifications were slightly more often HER2 positive compared to the other tumour features in terms of distribution.
However,
we found no statistically significant difference in multivariate analyses of association between mammographic features and HER2 status (table 1).
There was a significant difference (p-value <0.05) in the distribution of mammographic features across molecular breast cancer subtypes (table 2).
For example,
of the spiculated tumours 215 (67.4 %) were luminal A-like while only 10 (3.1 %) were TNBC.
In the distinct mass group 95 (46.8 %) was luminal A-like while 35 (17.2 %) were TNBC.