Liver, Interventional non-vascular, Oncology, MR, Digital radiography, Biopsy, Cholangiography, Drainage
D. Frantsev, O. N. Sergeeva, M. A. Shorikov, M. Lapteva, E. Virshke, B. Dolgushin; MOSCOW/RU
Methods and materials
The intraprocedural adverse events of 159 EPDT’s performed in 62 biopsy confirmed non-surgical Klatskin tumor patients in a ten-year period were studied.
The endobiliary light delivery was fulfilled though the previously inserted percutaneous transhepatic biliary drainage channels by mean of a 600 µm in diameter optical fiber with a 2 to 6 cm diffuser tip after prior 2 to 5 hours i.v.
injection of chlorin photosensitizers ( Fig. 5 ).
Intraprocedural adverse events included pain,
nausea and vomiting.
They were distributed into 3 grades: 1 – no or requiring medication only; 2 – requiring fluence rate reduction; 3 – requiring procedure cessation ( Fig. 6 ).
Their dependence on total dose (range 64.6-3240 J),
fluence rate (range 19,1 - 288 mW/cm2),
power density (range 14,5-206,3 J/cm2),
diffuser tip length (2,3,5,6 cm) ,
number of channels (range 1-4),
photoexposure time (range 3-240 min),
photosensitizing drug (Photolon,
Radahlorin) and its dosage (0.6-2.0 mg/kg) was analyzed ( Fig. 5 ).