Keywords:
Genital / Reproductive system male, Hybrid Imaging, Oncology, PET-CT, CT, Diagnostic procedure, Molecular imaging, Radiobiology, Neoplasia, Multidisciplinary cancer care
Authors:
M. Garcia Fontes1, V. V. Gigirey2, M. Rodriguez Parodi2, L. Servente2, G. dos santos2, L. Valuntas2, E. Otero2, B. Escudero2, O. Alonso2; 1Montevideo, MV/UY, 2Montevideo/UY
DOI:
10.26044/ecr2019/C-1730
Aims and objectives
Prostate cancer is the most common non-cutaneous malignancy in men in the Western world.
It represents an extremely variable disease with a very different biological behavior from an indolent disease to a very aggressive one and with extensive dissemination.
Within the wide variety of imaging studies for its evaluation,
PET/CT with 68Ga-PSMA has proved to be an accurate imaging technique.
Although this radiotracer has high sensitivity,
the specificity is relatively low,
both at initial diagnosis and recurrence.
Despite its name,
68Ga-PSMA is not a prostate-specific one .
For example normal physiological uptake is seen in small intestine cells,
renal tube cells,
celiac lymph nodes and salivary glands.
It is important to note that normal celiac lymph nodes are positive up to 89% of patients with prostate cancer.
On the other hand,
many benign and malignant tissues may show PSMA accumulation such as inflammatory processes and solid malignant tumors.
This uptake takes place mainly in the endothelial neovascularization cells.
The objective is to analyze the unexpected findings of 68Ga-PSMA PET/CT in patients studied for biochemical relapse of prostate cancer.
We highlight that our center is the only PET center of the country with universal country coverage under the Integrated National Health System.