Aims and objectives
is de novo hypertension (>140/90 mmHg) appearing after 20 weeks of gestation accompanied by proteinuria (>0.3 g/24hr). It is the leading cause of maternal mortality worldwide,
affecting 5-10% of pregnancies. Prevalence of PrE in South-South Nigeria is 5.7%.
The pathophysiology of PrE is related to incomplete trophoblastic invasion of the myometrium leading to limited remodeling of spiral arteries during the first and early second trimester. This impaired placental perfusion caused by these vascular abnormalities precedes clinical manifestations of PrE and Uterine Doppler (UtAD)...
Methods and materials
Study Design:This was a prospective,
cohort study of uterine artery Doppler US parameters in healthy pregnant women conducted between July 2016 to June 2017 at Braithwaite Memorial Specialist Hospital (BMSH),
a tertiary hospital located in Port-Harcourt city,
Rivers state in southern Nigeria.
Study Population: One hundred and seventy (170) apparently healthy women with singleton pregnancies between 18 and 26 weeks gestation (LMP or early ultrasound determined) were recruited by consecutive sampling from the Antenatal Clinic (ANC).Women with co-existing medical conditions (e.g Hypertension,
The demographic characteristics of participants are shown in Table I. Mean age was 31.6 ± 4.9 years,
and about half (48%) of them were nulliparous.
Table 1: Demographic characteristics of the study population
Age (years) mean ( ± SD)
Parity n (%)
BMI mean ( ±SD)
Previous PrE n (%)
Previous GDM n (%)
Thirteen women(8%) developed PrE...
Prevalence of PrE in the index study was 7.6%.
There was significant association between S/D ratio result and development of pre-eclampsia (p= 0.003).
The specificity was higher (88% vs.78%),
while the sensitivity was lower (46.2% vs.
71%) than reported by Madazli et al. These differences may be due to much higher prevalence of PrE (11.5%) in their studied population ordefining differentlyan abnormal result as S/D >2.6.
Mean RI showed no significant association with development of pre-eclampsia and is consonant with findings by Naategaal in Australia....
The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the international society for the study of hypertension in pregnancy (ISSHP).
Maternal preeclampsia and neonatal outcomes.
Factors influencing the prevalence of Preeclampsia- eclampsia in booked and unbooked patients : 3 years retrospective study in NDUTH ,