Education and training, Diagnostic procedure, CT, Abdomen
F. Arnone, M. Dimarco, R. Cannella, D. Giambelluca, L. Pennisi, V. Putortì, A. Lo Casto, M. Midiri; Palermo/IT
NETs are a rare and heterogeneous group of neoplasms,
which are derived from APUD cells,
the so-called amine precursor uptake and decarboxylation properties system,
ubiquitously found in the digestive tract,
respiratory system and producing serotonin and histamine-like substances.
It was O.
a German pathologist native of Berlin,
et al  in 1888,
at the University of Munich,
who provided the first detailed description of a carcinoid tumor.
He gave the description of ileal carcinoids,
called “little carcinomata”,
originating in the intestinal crypts of Lieberkühn.
Neuroendocrine cells have dense core granules that readily stain with silver stains (also called argentaffin cells) and similarity to neural cells (expression of synaptophysin,
neuron-specific enolase and chromogranin A),
with the absence of axons and synapses.