Type:
Educational Exhibit
Keywords:
Neuroradiology brain, MR-Functional imaging, Diagnostic procedure, Seizure disorders
Authors:
J. Herbert1, K. Kawsar1, M. Harley1, N. Davies 2, R. Flintham2, A. Zisakis1, D. McCorry1, R. Chelvarajah1, V. Sawlani1; 1Birmingham/UK, 2Birmingham /UK
DOI:
10.26044/ecr2019/C-1997
Background
Anterior temporal lobectomy is an effective therapy for refractory medial temporal lobe epilepsy but may significantly damage memory.
Patients with refractory epilepsy who may undergo temporal lobe surgery need precise information about their postoperative memory prospects.
Historically,
the prediction of potential postoperative memory deficits was based on neuropsychological measures and the Wada test.
This involves an invasive procedure involving cerebral angiogram and intra-carotid injection of 140 mg of sodium amytal.
Language and memory are assessed while hemiplegia persists.
fMRI has substantial potential to lateralize memory functions and predict post-operative memory outcome in epilepsy patients undergoing temporal lobe epilepsy surgery.1,2 However,
fMRI paradigms involving words and pictures encoding and retrieval task often fail to localize and lateralize memory in epilepsy patients in the clinical setting.