Efficacy and safety profile of SN132D, a novel nanoparticle MRI contrast agent

Congress:

ECR 2019

Poster Number:

C-2061

Type:

Scientific Exhibit

Keywords:

Cancer, Diagnostic procedure, Contrast agent-intravenous, MR, Contrast agents, Breast

Authors:

M. Hansen, S. Bäckström, L. Egeblad, A. Olsson, T. Sivik Sonne, O. Axelsson; Lund/SE

DOI:

10.26044/ecr2019/C-2061

DOI-Link:

https://dx.doi.org/10.26044/ecr2019/C-2061

Aims and objectives

SN132D is a nanoparticle-based contrast agent which uses manganese (Mn) as paramagnetic agent. The composition offers a slow wash out, which enables high resolution MR imaging over a few hours after administration and accumulation in malignant tissue to enable enhanced tumor selectivity. A thorough investigation of SN132D has been performed:

To analyze the relaxometric behavior of SN132D and to investigate the relationship with the microenvironment in which the nanoparticles distribute once administered in vivo
To show efficacy of SN132D in breast cancer tumor models in mouse and rat
To perform toxicity and safety pharmacology studies of SN132D both in-vitro, and in-vivo in rat and minipig