Biophysical modelling of the effect of Alzheimer's plaques on MRI

Congress:

ECR 2019

Poster Number:

C-2511

Type:

Scientific Exhibit

Keywords:

CNS, MR physics, Neuroradiology brain, MR, Image manipulation / Reconstruction, Experimental, Experimental investigations, Physics, Molecular imaging, Dementia, Image verification, Pathology

Authors:

E. Tuzzi, M. Baez, K. Scheffler, G. E. Hagberg; Tübingen/DE

DOI:

10.26044/ecr2019/C-2511

DOI-Link:

https://dx.doi.org/10.26044/ecr2019/C-2511

Fig. 1: Fig. 1. Left: β-amyloid stain. Right: simulation of the magnetic field effect...

Fig. 2: Fig. 2. Left: β-amyloid stain. Right: simulation of the magnetic field effect...

Fig. 3: Fig. 3. Phase maps (Hz) obtained by averaging field maps for voxel size ≥ 100...

Results

At small voxel sizes (≤100µm) the magnetic field effect caused by single β-amyloid plaques could be observed (Fig. 1). At the voxel size of 100µm, which is close to the spatial resolution achievable with clinical protocols at ultra high field strenght (≥7T), single plaques effects could not be observed. However, a clear pattern due to the palques can be distinguished at this spatial resolution (Fig. 2).

For greater voxel sizes (500µ and 750µm), only the combined effect of several plaques was detectable. However, even at voxel sizes of 1mm, that can be used on clinical scanners operating at 3T, the magnetic field effect was still noticeable (Fig. 3).