Aims and objectives
CT-guided Radiofrequency Ablation (RFA) is an established interventional method,
indicated for treating a wide variety of tumors and has been well-used among adult population.
It produces coagulative necrosis of tumor through local tissue heating.
RFA application among pediatric patients suffering from advanced malignancies is not widely spread,
whereas the relative literature remains poor[1,2].
On the other side RFA is established as a treatment therapy for osteoid osteoma in this group of patients [2,3].
As the host of clinical applications for RFA expands continuously,
Methods and materials
All human studies have been approved by the hospital’s ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
We retrospectively reviewed 20 cases regarding pediatric patients,
who underwent RFA in our department between September 2010 and January 2018. Relative pre- procedural management included laboratory tests (Hemoglobin concentration,
international normalized ratio [INR],
partial thromboplastin time and platelet count),
parents’ consent and fasting 12hours prior to the procedure .
A total of 20 pediatric oncologic patients with metastatic malignancies underwent 24 RFA ablation sessions.
Our study population included 12 male and 8 female patients of average age 9years (5-17years),
whereas our patients’ average weight was 30kg (17g-65kg).
Regarding lesions’ location,
half of our patients (50%) have been treated for metastasis in hepatic parenchyma. Out of the rest in 5 patients (25%) bone metastatic lesions have been ablated and 5 patients (25%) received RFA session due to lung metastatic disease [solitary- 4 patients (20%) ,...
Advanced malignancies consist the second most common death cause among children,
though less prevalent compared to adult population.
Childhood cancer presents also,
compared to adult malignancies a different spectrum of prognosis,
location and histology,
as certain types of cancer are strongly associated with childhood while discrepancies are shown up concerning treatment options.
Metastatic malignancies in solid organs,
such as lung,
liver or bones are rare.
On the other hand RFA has been an established technique particularly regarding benign lesions such as osteoid osteoma or cardiac...
Li M et al (2008) Percutaneous radiofrequency ablation for treatment of hepatoblastoma recurrence.
Pediatr Radiol 38:1021–1023.
Thanos L(2014).CT-guided radiofrequency tumor ablation in children.Pediatr Radiol.
vanSonnenberg E (2007) Issues in imaging-guided tumor ablation in children versus adults.
AJR Am J Roentgenol 189:626–632.
Brú C et al (2001) Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma.