Keywords:
Paediatric, Oncology, CT, PET-CT, Staging, Lymphoma
Authors:
K. Khasanova, I. E. Tyurin, V. Sinitsyn; moscow/RU
DOI:
10.26044/ecr2019/C-3143
Results
96
PET/CT results were compared with CE CT.
Of the 264 that were considered fo the analysis PET/CT and CT were judged as concordantly positive in 234 regions (86%).
F-18 FDG-PET and CT were discordant in 42 regions(16%),
with a positive result on F-18 FDG-PET and negative findings on CT in 37 regions (14%).
In the remaining 5 regions (1,8 %),
F-18 FDG-PET was reported as negative and CT as positive.
After CT staging,
PET/CT findings resulted in a change of the disease staging in 31patient (40,2%): upstaging in 26 (33,7%),
downstaging in 5 (6,5%) patients.
All findings were proven by histopathology and by clinical follow-up.
The upstaging of the disease was mostly because of:
- bones and bone marrow involvment that was missed on the CT (22,7%,
n=18) (Fig.1-4)
· liver invovment (9%,
n=6) (Fig.7)
· abdominal lymph nodes involvment (4,5%,
n=3) (Fig.8-9)
The downstaging of the disease was mostly because of neck and abdominal lymph nodes.
Only one child out of the 77 patients (1,8%) was not accurately staged by PET/CT.
It was the false-positive extranodal lesion in thyroid gland with high FDG metabolism which turned out to be a simple non-toxic goiter (Fig.10))
Other missed regions by the PET/CT (cervical lymph nodes and lungs) didn't change the stage of the disease.
Overall sensitivity and specificity for PET/CT were 90% and 98% respectivly.
The sensitivity and specificity for CT were 75% and 89% respectivly.