Keywords:
Musculoskeletal soft tissue, Absorptiometry / Bone densitometry, Experimental investigations, Laboratory tests, Statistics, Geriatrics, Inflammation
Authors:
A. Bazzocchi, C. Gasperini, A. Santoro, T. Tavella, S. Rampelli, C. Fabbri, G. Guidarelli, D. Mercatelli, E. Giampieri; Bologna/IT
DOI:
10.26044/ecr2019/C-3317
Results
Beta-diversity of the microbial communities is represented by Principal Coordinate analysis (PCoA) of the unweighted Unifrac distances.
Three distinct groups of individuals with different microbiota composition were identified (Fig.
1) (Permanova p-value = 0.0001): group A (n=147),
group B (n=20) and group C (n=34).
No differences between non-frail/pre-frail or male/female subjects were observed.
A significantly different relative abundance of the Families Porphyromonadaceae,
Christensenellaceae and Lachnospiraceae was identified among the three groups (P < 0.05,
Kruskal Wallis test) (Fig.
2 - Table 1).
The comparative analysis showed a higher abundance of Porphyromonadaceae and Christensenellaceae in group B,
while Lachnospiraceae showed a higher relative abundance in the microbiome of group B and C.
Group B,
characterized by a higher abundance of Christensenellaceae family and lower VAT,
showed a significant association between the microbiota configuration and VAT (p=0,003).
No significant differences were found among groups for SAT (Fig.
3).