Tissue characterisation, Inflammation, Connective tissue disorders, Diagnostic procedure, MR, Cardiovascular system, Cardiac
V. Bordonaro1, G. Rovere2, V. Vingiani2, R. Marano1, A. Meduri2, B. Merlino1, L. Natale2, R. Manfredi1; 1Rome/IT, 2Roma/IT
ACTDs are a heterogeneous group of autoimmune diseases with systemic involvement,
characterized by progressively irreversible multi-organ damage.
The most common forms of ACTDs include scleroderma (systemic sclerosis - SSc),
systemic lupus erythematosus (SLE),
inflammatory myopathies and Sjögren's syndrome.
Mixed connective tissue diseases (mixed-ACTDs) should be considered in Pts with overlapping clinical features,
in which there is an autoimmune condition that does not meet the criteria for a specific form.
the clinical manifestations of ACTDs are characterized by a wide variability and the clinical management is mainly driven by symptoms due to articular,
renal or neurological involvement.
The prevalence of cardiovascular involvement in ACTDs has long been underestimated: cardiac alterations often remain silent and largely undetected as they culminate in potentially severe conditions such as dilated cardiomyopathy (DCM),
rapidly evolving heart failure (HF) and arrhythmias.