Cardiac, Cardiovascular system, Kidney, CT, Computer Applications-General, Computer Applications-Detection, diagnosis, Calcifications / Calculi, Arteriosclerosis
G. Rovere, V. Vingiani, F. Paciolla, M. Muciaccia, G. Savino, B. Merlino, P. M. Ferraro, R. Marano, R. Manfredi; Rome/IT
There were 108 (60.0%) patients with AAC; those patients were older,
had a significantly higher prevalence of diabetes,
high blood pressure,
lower eGFR and a tendency towards a higher prevalence of male gender.
In univariate analyses,
calcium phosphate content was significantly directly associated with eGFR (rho 0.34,
p < 0.001) and inversely with age (rho −0.27,
p < 0.001),
and was higher among females (17.8 ± 29.2% vs 8.6 ± 20.3%,
p = 0.011); conversely,
uric acid content was associated directly with age (rho 0.16,
p = 0.028) and inversely with eGFR (rho −0.34,
p < 0.001),
and was higher among males (22.3 ± 39.4% vs 7.9 ± 25.4%,
p = 0.006),
patients with diabetes (48.5 ± 48.3% vs 14.9 ± 33.6%,
p = 0.002) and high blood pressure (33.2 ± 45.6% vs 15.5 ± 34.1%,
p = 0.06).
Calcium oxalate content and other constituents were not significantly associated with any variable.
The results of the substitution model assessing the association between the stone composition and AAC are reported in Table 2.
In unadjusted analyses,
none of the stone constituents was significantly associated with AAC,
except for a borderline significant direct association between uric acid content and AAC.
after adjustment for age and gender,
there was a significant association between calcium phosphate content and AAC: a 10% shift in stone weight from calcium oxalate to calcium phosphate was associated with 25% higher adjusted odds for AAC (OR 1.25,
95% CI 1.00,
p = 0.045).
Further adjustment for diabetes,
high blood pressure and eGFR did not significantly change the results. No significant interaction by gender was found between calcium phosphate content and AAC (p = 0.84).